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ICC represents a ratio of true variance over total variance (i.e., true variance plus error variance), indicating the extent to which measurements can be replicated

Whilst the pentamer is resistant to proteolysis, the monomeric CRP can be proteolyzed by a variety of neutrophil-derived peptidases, and peptides can inhibit the activation of platelets and neutrophils, thereby down-regulating the potent proinflammatory activities of the intact monomer [63]

Advantages include its established safety history and FDA clearance for use in adolescents as young as 12 years old

Cyster et al., 2014

He was interred in Green-Wood on May 14, 1850

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