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95% CI: 6.25 to 1.75

GLP-1RAs reduce events linked to atherogenic cardiovascular disease (especially ischemic stroke) and also renal outcomes (FLOW trial with semaglutide), with a limited effect on heart failure

GLP-1RAs are a relatively new class of injectables that are effective at reducing HbA 1c , have a low risk of hypoglycaemia when given as monotherapy or in the absence of sulphonylureas (SU) or insulin, and have the potential for weight losskey considerations when treating a typical obese patient with T2DM [4]

He says there's very little data on whether or how the dose should be titrated to wean patients off, or how to adjust when your appetite and cravings start to return

Preservation of muscle and bone mass The adverse effects of weight reduction on muscle and bone massparticularly among individuals with insufficient physical activity or protein intake or at older ages [59,149]have highlighted the interrelated priorities to preserve muscle mass, muscle quality, bone mass, and physical function
