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For smaller doses, 0.5 mL (50 unit) or 0.3 mL (30 unit) syringes provide better precision

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Side Effects of Neuromodulators The worst that people generally experience is some pain at the injection sites and/or headache, and maybe some symptoms of a cold or upper respiratory virus

However, there are multiple pathways that result in upregulation of COX-2 in brain neurons, including increased N-methyl-D-Aspartate (NMDA) receptor-dependent activity (230), cerebral ischemia, seizures, and diseases such as AD or PD (231)