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In an experimental rat model using endosulfan to cause testicular toxicity, endosulfan has appeared to induce oxidative stress and apoptosis, as demonstrated by increased H2O2 levels, lipid accumulation and reduced activity of anti-oxidant enzymes (SOD, CAT, GPx), as well as altered reduced GSH content and mitochondrial cytochrome c release (275)

Hyperglycemia in DKD significantly disrupts endothelial permeability, primarily mediated by enhanced oxidative stress, inflammatory factors, and sorbitol production (94)

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Unlike typical amino acid connections, glutathione has a special -carbonyl group that links glutamate and cysteine

Many studies have shown that artemisinins produce ROS in parasites and cancer cells, while Egwu et al

Abbreviations AFP: Alpha-fetoprotein ALT: Alanine transaminase Apo B: Apolipoproteins B Apo-A1: Apolipoproteins A-1 AST: Aspartate aminotransferase A-T: Ataxia-telangiectasia ATM: Ataxia-telangiectasia mutated BMI: Body mass index CVDs: Cardiovascular diseases FAPESP: So Paulo Research Foundation GGT: Gamma-glutamyl transpeptidase GPx: Glutathione peroxidase activity H/A: Height for age HD: Heart disease HDL-c: High-density lipoprotein cholesterol HOMA-IR: Homeostasis Model Assessment of Insulin Resistance IEI: Inborn errors of immunity IQ: Interqartile interval IVIG: Intravenous immunoglobulin LDL-c: Low-density lipoprotein cholesterol LDLox: Oxidized LDL MDA: Malondialdehyde MUAC: Mid-upper arm circumference NCEP: National Cholesterol Education Program NFkB: Nuclear transcription factor NHDL-c: Non-HDL-c ROS: Reactive oxygen species Se: Selenium TC: Total cholesterol TG: Triglycerides us-CRP: Ultra-sensitive C-reactive protein VLDL-c: Very-low-density lipoprotein cholesterol References Cardoso BR, Ganio K, Roberts BR