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The resistance of hepatocellular carcinoma cells to chemotherapeutic agents such as sorafenib involves the abnormal expression of multiple transcription factors such as Nrf2, retinoblastoma (Rb) protein, hepatocyte nuclear factor 4(HNF4), HIC ZBTB Transcriptional Repressor 1 (HIC1), O-GlcNAcylated c-Jun, YAP/TAZ

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Integrins are transmembrane receptors connecting the extracellular matrix to the actin cytoskeleton of the cells and thereby acting as a sensor for cell adhesion 66

3) Inflammatory mediators: inflammatory cytokines not only induce iron accumulation but also directly activate ferroptosis pathways