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[PMC free article: PMC5946415] [PubMed: 29747678] 68

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While research in female rodents is limited, research in male rodents suggests that ketogenic interventions initiated at midlife may slow age-related cognitive decline, as well as preserve muscle mass and physical function later in life

Pinealectomy results in the accelerated neurodegenerative changes and evidence of premature aging in animals [150,151,152,153]

This happens because the body produces more pigment when certain protective substances like glutathione are low