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The link between TMAO and MAFLD was first confirmed by a cross sectional observational study conducted by Chen and colleagues, they detected the plasm TMAO levels of healthy people and patients with MAFLD and found that the TMAO level of patients with MAFLD (0.434 M) is 4.17 times higher than that of healthy controls (0.104 M) (Younossi, 2019)

PCs significantly promote wound healing by alleviating oxidative stress, promoting endothelial progenitor cell migration, improving angiogenesis, and exerting anti-inflammatory and antibacterial effects

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Though, CLEC have needed of that the enzyme be crystallized, it is necessary that it is highly purified but to crystallize the enzyme, which is a very costly process, assembling the immobilization procedure sophisticated and expensive [183]

The peptide's effects on energy homeostasis extend beyond appetite suppression to include modulation of nutrient partitioning and fuel utilization

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