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However, by using different FLNA dominant negative mutants that selectively abolished the ability of FLNA to interact with SST2 (FLNA repeats 1920) or to function as scaffold for partner proteins (FLNA 2124), the authors demonstrated that FLNA plays both a structural role, by stabilizing SST2 expression after prolonged stimulation with a specific agonist, and a functional role, acting as scaffold protein for molecules involved in signal transduction

Bioprocess Biosyst Eng 32:729735

E., Hayes, M

The practice is rooted in alternative medicine and was popularized in the 1920s and 1930s by the Gerson Therapy, which aimed to detoxify the body and promote healing through diet and coffee enemas

doi:10.1073/pnas.0230374100