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Glutaminase inhibition with telaglenastat (Cb-839) improves treatment response in combination with ionizing radiation in head and neck squamous cell carcinoma models

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Researchers have observed this protective effect through glutathiones activation of the Nrf2/HO-1 signaling pathway [4]

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Figini M, Obici L, Mezzanzanica D, Griffiths A, Colnaghi MI, Winter G, et al

These differences were also evident in the track plots: the AD model rats spent more time in the centre of the apparatus before finding their way to the enclosed arm, whereas the FD-treated rats took a more direct route to enter the enclosed arm