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As a result, it can help widen blood vessels and reduce blood pressure

Ampk/ulk1-mediated phosphorylation of parkin act domain mediates an early step in mitophagy

It is needed for neurotransmitter reuptake, endocytosis of SV, and presynaptic vesicles, let alone maintain the concentration gradients of ions across the membrane

We propose a cellular model of CVS in which an aberrant ion gradient begets mitochondrial dysfunction which begets further anomalous ion gradients, etc., forming a pathogenic vicious cycle leading to cellular hyperexcitability (Figure 1)

Lefkowitz, R

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