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Importantly, this process is dynamic and can be maintained by transcriptional changes within the dorsal root ganglion (DRG), where the cell bodies of nociceptors upregulate the production of pronociceptive peptides like substance P and calcitonin generelated peptide (CGRP), further fueling neurogenic inflammation upon peripheral release
Here we performed an extensive multi-omic analysis evaluating cytokines, lipid mediators, and reactive oxygen species as well as cellular immune, transcriptional, and epigenetic profiles in a cohort of participants approximately 4 months following their first episode of COVID-19 and investigated whether these responses associate with the presence of LC symptoms

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