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The trial was conducted in accordance with the Declaration of Helsinki and Good Clinical Practice guidelines

In animal studies, low-dose berberine attenuated 6-OHDA-induced loss of dopaminergic neurons and hypokinesia in zebrafish, whereas high-dose berberine had no apparent effect (Zhang et al., 2017)

In patients with mutations in the C9ORF72 gene, the production of harmful dipeptide repeat proteins further disrupts communication between the nucleus and cytoplasm, impairing cell function

Its anti-inflammatory properties also help reduce redness and irritation, making it suitable even for sensitive skin

Osteoclasts, responsible for bone resorption, drive bone destruction in RA, influenced by factors like receptor activator of nuclear factor kappa- ligand (RANKL), interleukin-1 beta (IL-1), interleukin-6 (IL-6), and TGF-

Laboratories using the compound in time-course or dose-response work should prepare fresh aliquots where possible, recording reconstitution date and storage temperature alongside each experimental block