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Additionally, the gastrointestinal adverse effects commonly experienced with tirzepatideincluding nausea, vomiting, and reduced appetitemay lead to decreased dietary intake and potential nutritional deficiencies over time

J Appl Phys (2021) 129(16):163301

Longitudinal studies are needed to further investigate the cause-effect relationship between VitB12 and insomnia and establish a safe and adequate VitB12 supplementation level in patients with T2DM

On top of the already discussed benefits for energy levels and combating stress, taking vitamin B12 on an empty stomach will aid absorption by creating an acidic environment the same goes for all nutrients that are not fat-soluble

These reasons, while understandable from a procedural standpoint, can be clinically and emotionally detrimental to a patient with Pernicious Anemia who is symptomatic and in need of treatment

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