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6 PMC (2022)Reduced-calorie diet with NNMT inhibition establishes a distinct microbiome in DIO mice

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Mechanisms include: Restoration of endothelial nitric oxide synthase (eNOS) Upregulation of VEGF and FGF-2 (fibroblast growth factor 2) Reduction of oxidative stress and cytokine-induced apoptosis BPC-157 preserved endothelium-dependent vasodilation via upregulation of eNOS and suppression of vascular inflammation. Gwyer Findlay et al., Peptides 4

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Some researchers use higher doses up to 1000mcg per administration when targeting more aggressive recovery goals