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10.1016/j.fob.2014.05.002 FEBS Open Bio 79 Reidy-LagunesD

Although GSH extrusion may provide a simple mechanism to circumvent the normally protective functions of GSH, there is increasing evidence that GSH export is required for activation of specific apoptotic signaling pathways and/or for proper dismantling of cellular components (Coppola and Ghibelli, 2000

76 In contrast, silencing and down-regulation of cellular BNIP3 levels by siRNA inhibited mitophagy, which led to an increasing ROS level and a decreased protein level of the antioxidant MnSOD

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SAG S-acetyl-glutathione a method for increasing circulating and/or intracellular levels of glutathione comprises orally administering to an individual in need thereof a delayed-release, gastro-resistant capsule which contains an amount of S-acetyl-glutathione (SAG) effective to increasing circulating and/or intracellular levels of glutathione

Therefore, we cannot directly conclude that the observed improvements in endocrine-metabolic profiles and oxidative stress in PCOS mouse ovaries following NAC intervention lead to enhanced fertility