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It manifests as hyperfibrinogenemia (reflecting hepatic acute-phase activation), thrombinemia, intravascular platelet activation and aggregation, intravascular paracoagulation, and impaired fibrinolysis [910,1017,1018,1019]

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doi: 10.1271/bbb.100840

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However, despite the initial high hopes and decades of compelling findings, interest in these molecular chaperones has markedly declined over the past decade

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