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As CD4+ cell levels become depleted with advancing HIV infection, viral replication within macrophages, dendritic cells, and other cell types sustains viral load

Soleimani V, Delghandi PS, Moallem SA, et al

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Apr 2004;70(4):399-401

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To the possible persistence of the initial pathogen that triggered the PAIS, one should add the reactivation of latent viruses such as EBV, HHV-6 or VZV (8285), all frequently observed in PAIS, possibly as a result of a reduced efficiency of their control by the immune system