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Mushrooms are well-known for their capacity to bioaccumulate a wide range of elements from their growing environment, including heavy metals (e.g., lead, cadmium, mercury, and arsenic) as well as emerging metals like as platinum (Pt), palladium (Pd), and rhodium

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Recently, the latent roles of AMPK signaling in tumorigenesis and progression have been gradually revealed (233)

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[] Overproduction of ROS caused by exposure to heavy metals begins from cellular metabolism at the mitochondria and eventually reaches all cellular components and tissues which causes oxidative stress which then can result in the apoptosis of cells