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The present study confirmed the significantly lower activities of SOD in plasma of patients with active CD

Copper concentrations in the cerebellum also increased with age, but in AD mice, while copper levels did not significantly change (MannWhitney U , p = 0.063), significant changes in copper isotope ratios were observed (MannWhitney U , p = 0.016), with a notable enrichment in copper isotope ratios in AD transgenic mice (65Cu = 0.33) (81)

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Chemotherapy and radiation can also induce ferroptosis by disrupting redox balance

Many explanations are possible, but I reason as follows