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Therefore, HIF-1 likely exerts a suppressive effect on ferroptosis in affected cells by upregulating antioxidant systems, exerting a protective role similar to its anti-apoptotic effects in osteoblasts

however, these effects were proportionally larger, with large effect sizes on most measures

doi: 10.1080/01443615.2016.1264375 136 SalehpourSNazariLHoseiniSMoghaddamPBGachkarL

Keller, Brad M

Redox regulation at the level of the secondary sulfur metabolic pathway While SOT represent the largest protein family among sulfate-assimilating proteins, their biochemical and functional characterization still lags behind and this is also true for the associated regulation mechanisms

Therefore, the synthesis of new organoselenium compounds in the future provides new options for fully utilizing the functions of GPX family members