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Since 1990, there has been a significant increase in mortality attributed to neurological diseases, with a rise of approximately 37% from 6.87 million to 9.40 million

Other groups, such as DFCI, COG, and BFM, are now limiting radiation therapy to patients with very high-risk features or CNS3 disease

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Phase-I metabolites are highly apt to form adducts with proteins and nucleic acids because of their electrophilic character

282,283 Several natural phytochemicals, such as curcumin, have also been shown to inhibit NF-B nuclear translocation while simultaneously activating Nrf2, an antioxidative pathway

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