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10.1002/jnr.20195 44

Glutathione has a protective effect in normal tissues

Furthermore, IGF-1 can provide neuroprotection from oxidative danage by interacting with trophic factors secreted by astrocytes in conjunction with H 2 O 2 , such as stem cell factor (SCF) [132]

Fortunately, most people will never develop esophageal cancer

Another indication of the possible usage of Grx as a biomarker in specific tumours come from studies reporting Increased expression of Grx3 specifically in colon [220] and in bladder tumours [221] while Grx1 has been reported as a possible malignant marker in pancreatic duct carcinomas [222] and in the study by Zhao and collaborators, who sought non-invasive urinary markers for HCC, Grx1 expression decreased [219]

The membranes were blocked using 5% skim milk for 1 h at room temperature, then incubated overnight with primary antibodies at 4