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Specifically, direct action on ion channels results from neurotransmitter binding to receptor sites on the membrane of postsynaptic neurons

Annals of the Academy of Medicine, Singapore, 53 (4), 241252

[598] Moreover, impaired functional capacity is associated with poorer quality of life and an increased risk of all-cause mortality, postoperative complications, and cognitive impairment, the latter of which can complicate the return of a patient to the community from post-acute care

Prevalence of multiple chronic conditions among US adults: estimates from the National Health Interview Survey, 2010