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doi: 10.1212/WNL.0000000000002087

Additionally, the route of drug administration is crucial, where oral gavage, which more closely mimics human oral intake, is a more appropriate method for drug delivery in these models

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Interestingly, lycopene also reactivated GSTP1 gene expression through reduced promoter methylation in MDA-MB-468 breast cancer cells (King-Batoon et al., 2008)