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Individuals considering extended protocols should understand this temporal limitation in the safety database

The analysis of covariance (ANCOVA) test was used to determine the differences between the two groups while adjusting for baseline measurements and covariates

The following criteria were considered: Full economic evaluations: cost-utility analysis, cost-effectiveness analysis, cost-benefit analysis Economic evaluations reporting incremental cost-effectiveness ratios (i.e., cost per quality-adjusted life year/life years gained or cost per event avoided) Studies in patients with confirmed vitamin B12 deficiency Studies in English Abstracts were reviewed by a single reviewer and, for those studies meeting the eligibility criteria, full-text articles were obtained