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The protocol is 2 months on, 2 months off, with a 2-week ramp-up at 5 units before increasing to 8 units for weeks 3 through 8, 5 days on and 2 days off

A headache diary covering at least 4 weeks prior to your appointment is strongly recommended to support your consultation

It influences the expression of numerous genes responsible for cell proliferation, differentiation, and migration, essential for the repair of damaged tissues

Both methods can effectively raise your vitamin B12 levels, but they work differently

We are thankful to Biorender.com for the preparation of the figures

doi: 10.1038/s43018-020-00124-1 89 GriffithOW