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Dart RC, Kuffner EK, Rumack BH: Treatment of pain or fever with paracetmol (acetaminophen) in the alcoholic patient: a systematic review

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Although PCG-1 is confined to the nucleus (Wu et al., 1999), it is thought to affect the replication and expression of many mitochondrial genes by interacting with a variety of proteins and stimulating downstream signaling pathways

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doi: 10.1016/j.yexcr.2018.02.016

History of persistent widespread pain extending over three months 2