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Reactive astrocytes with reduced function of glutamate transporters in the App(NL-G-F) knock-in mice

The good news is that we can increase glutathione levels by supplementation

This is a qualitative, mechanistic distinction between the two intervention categories, and it is why the research literature treats endpoint agonism and upstream secretagogue stimulation as fundamentally different manipulations of the somatotropic axis rather than two routes to the same outcome

doi: 10.1038/s41588-022-01270-1 28 OrrVSteriMSidoreCMarongiuMSerraVOllaSet al

NAC : Has unique neuroprotective effects by regulating glutamate, the brains main excitatory neurotransmitter

Expert Opin Drug Metab Toxicol 5:243257 Rautio J, Meanwell NA, Di L, Hageman MJ (2018) The expanding role of prodrugs in contemporary drug design and development
