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In line with these results experiments performed with an in vitro human BBB model showed that under hypoxic conditions activation of NRF-2/HIF pathways led to overexpression of P-gp although a distinct expression profile of BCRP was observed [79], while inhibition of HIF-1 can prevent ferroptosis [80]

5) as a response to increased intracellular Zn to counteract the damaging effects of increased free radicals, causing these MTs to also bind Cu from food, since MTs have a higher affinity for Cu than for Zn [337,338,339]

A low ratio of reduced vs

However, the results timeline varies for every individual

Each gram of the 0.05% ointment contains clobetasol propionate 0.5 mg in a base of propylene glycol, sorbitan sesquioleate, and white petrolatum

In addition, the authors used the SciSpace platform (SciSpace, New York, NY, USA) to generate scientific illustrations based on prompts developed by the authors, which were subsequently refined and incorporated into the figures presented in this manuscript