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At the catabolic level, they directly inhibit the myoprotein degradation process mediated by the ubiquitin-proteasome pathway by downregulating the expression of two core E3 ubiquitin ligases, atrogin-1 and MuRF-1

Poor biomechanics: Improper lifting techniques, faulty posture, or muscle imbalances in the shoulder and arm can alter biomechanics and increase stress on the triceps tendon

Tammaro A, Florquin S, Brok M, Claessen N, Butter LM, Teske GJD, et al

2018;8(1, article 12136) doi: 10.1038/s41598-018-30562-y

In addition, they upregulated the cystine/glutamate antiporter subunit SLC3A2 to counteract glutathione depletion, which attenuates ferroptosis (Melo et al., 2024)

Identification of pan-assay INterference compoundS (PAINS) using an MD-based protocol