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FIGURE 4 5.1 Antioxidant activity Oxidative stresscharacterized by excessive reactive oxygen species (ROS) accumulationinduces a redox imbalance that accelerates cellular senescence and contributes to multiple disease pathologies

The spectral features were log- transformed and further analyzed via MetaboLyzer (1) using 0.7 for ion presence threshold, p-value threshold of 0.05 using non-parametric Mann-Whitney U-test, and false discovery rate (FDR) correction set at 0.1 in the positive ESI and at 0.2 in the negative ESI mode

605 A subsequent phase III clinical trial, the PHOENIX trial, failed to demonstrate a significant difference between the treatment and placebo groups, leading to the withdrawal of the combination from the market

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