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Melanophages are usually numerous in the adjacent dermis, but a lymphocytic response is absent

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While PEGylation enhances circulation time and reduces immune recognition of nanoparticles, excessive PEGylation might hinder the efficient interaction of LNPs with target cells, leading to reduced therapeutic effects (Kumar et al., 2014), and fusion of the LNPs with the endosomal membrane due to steric hindrance, leading to therapeutic inefficacy (Aldosari et al., 2021

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This suggestion is partly based on findings from a randomized trial of 118 patients on isotretinoin that sought to evaluate efficacy of omega-3 in reducing mucocutaneous side effects of isotretinoin