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doi: 10.1152/jn.00207.2001

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Complete immobilization beyond what is necessary for fracture stability can actually impair healing by depriving the callus of the mechanical signals that guide remodeling

At 6 hpi, mice were intraperitoneally treated with 10 mg kg 1 Rif, alone or with 100 mg kg 1 KL1 in 7% DMSO, 40% PEG300 and 53% sterile H 2 O

The result: anxious thoughts dial down and concentration sharpens, without sedation or dependency

What the Evidence Actually Supports The 2025 AAOS systematic review (Vasireddi et al.) identified 35 preclinical and only 1 human study meeting inclusion criteria
