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Description
Cytosolic mtDNA activates the cGAS-STING axis, driving type I interferon responses and pro-inflammatory cytokine production, whereas extracellular or endolysosomal mtDNA stimulates toll-like receptor 9 (TLR9), leading to NF-B dependent inflammatory transcriptional programs
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As a control, we first used nisin, which clearly induced a decrease of pyrene monomer fluorescence that coincided with the appearance of a fluorescence peak around 490 nm, indicating the formation of excimers (Supplementary Figure 2), which is consistent with a previous study (Breukink et al., 2003)
10.1177/1744806919837429 101 LudmanT.MelemedjianO
W.HubbardA.MelovS.LithgowG
143:1109-1122 [PMC free article: PMC7969166] [PubMed: 33438437] 36
