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The combination increases gastrointestinal side effects

Note that the side chain of glutamate and the amide of cysteine are joined through a g-peptide linkage

This medicine may interact with certain antipsychotics (e.g., risperidone and quetiapine) and anti-seizure medications (e.g., carbamazepine and phenytoin)

These mechanisms together may explain why B12 has been studied in conditions such as diabetic neuropathy, nerve injury, and radicular pain syndromes similar to sciatica

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4 Discussion This is the first head-to-head study designed to evaluate the efficacy of PEG-Loxe versus insulin glargine on glycemic control measured by CGM in middle-aged and elderly patients with T2DM