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For most adults, a safe and effective range is 1,000 to 3,000 mg per day

J.et al (2018)

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Neuroimaging examinations, such as cranial MRI, may show enlarged ventricles, subventricular cysts, thinning of the corpus callosum, frontal subarachnoid and subdural effusions, delayed maturation of the brain (such as delayed formation of myelin sheaths), and so on [4, 59]