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While a study found declined levels of NAD + and NAMPT levels and mitochondrial function in human sarcopenic muscle 249 , another study demonstrated no notable difference in NAD + or NAMPT levels in sarcopenic muscle of human patients 262

Curie A, Touil N, Gaillard S, Galanaud D, Leboucq N, Deschenes G, Morin D, Abad F, Luaute J, Bodenan E, Roche L, Acquaviva C, Vianey-Saban C, Cochat P, Cotton F, Bertholet-Thomas A (2020) Neuropsychological and neuroanatomical phenotype in 17 patients with cystinosis

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doi:10.1023/A:1018955126402

A recent study showed in the FSP1/CoQ10 antioxidant system that the level of FSP1 was significantly reduced in the brain tissue surrounding hematomas in ICH mice, which could be treated with the drug dexpramipexole to reverse this harmful change (Wang B