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Life-threatening respiratory depression is more likely to occur in elderly, cachectic, or debilitated patients because they may have altered pharmacokinetics or altered clearance compared to younger, healthier patients [see WARNINGS

The aforementioned results obtained in the course of studies on oxidative stress parameters in migraine patients seem to confirm the involvement of oxidative stress in the pathogenesis of migraine (Table 1)

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Standard recommendations suggest treatment periods followed by equivalent rest periods

Consider coffee alternatives during afternoon hours to avoid exceeding recommended limits whilst maintaining energy levels throughout the day

[7] [9] What are the possible side effects