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This will help ensure the ingredients stay evenly mixed.

and study methodologies had multiple shortcomings

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Methylation is necessary for many key biochemical reactions in the body, including: Detoxification (including estrogen and endocrine disruptor detoxification) Neurotransmitter production Genetic expression (more on this below) Amino acid (protein) metabolism Growth and development (including pregnancy) Producing phosphatidylcholine for cell membranes Producing creatine for muscle health and strength Producing glutathione for antioxidant protection The methylation process requires specific nutrients to produce methyl groups