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All pretreatments increased binding of autologous IgG as well as of purified anti-band 3 NAbs and binding was inhibited by purified band 3 protein or by restoration of the protein SH groups (Beppu et al., Oxidation or a treatment with a clustering agent and cross-linking of the generated clusters evidently simulates the prerequisites for clearance of RBC, but does not explain how band 3 clusters are formed during in vivo aging

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The hypoxic TME further compounds ferroptosis resistance by stabilizing HIF-1, which reprograms lipid metabolism and enhances antioxidant defenses

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Curcumin treatment alleviated TGF-1-induced HK-2 cell apoptosis, inflammation, and fibrosis in vitro, as well as relieved renal injury in unilateral ureteral obstruction (UUO) mice models in vivo
