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drip at a rate of 150 mg/kg per h (0.3 mL/h) for 60 min starting 10 min before LPS administration (10 mg/kg by slow blous injection, i.v., over 1-2 min)

However, we suggested that the lethality induced by LCS3 in VRK2-KO PC cells is primarily dependent on inhibiting the activity of GSR rather than TXNRD1, for the following reasons

10 Reduced glutathione is associated with higher oxidative stress, 11 which contributes to damage 12 in the trabecular meshwork cells and retinal ganglion cells, worsening glaucoma and accelerating optic nerve damage

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10ShiaJHolckSDepetrisG (2013) Lynch syndrome-associated neoplasms: a discussion on histopathology and immunohistochemistry

For long-term storage of reconstituted solution, aliquot into single-use volumes and freeze at 80C under inert gas where possible