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A study revealed that DPP9 promotes chemoresistance in liver cancer by binding to KEAP1, stabilizing Nrf2, and upregulating NQO1 expression to lower ROS and reduce chemotherapy efficacy

2 Preclinical evidence and mechanistic studies This section summarizes the key in vitro and in vivo findings from preclinical studies of major classes of natural metabolites from TCMs with cardioprotective effects, and discusses the key molecular targets and pathways by which these natural metabolites exert their cardioprotective effects

Transcranial direct current stimulation in neurodegenerative disorders

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Vincristine caused a sharp increase in histone 3 phosphorylation at serine 10 (pS10-H3), likely due to its interference with mitotic spindle assembly, causing mitotic arrest ( Supplementary Figure S7A )

[DOI] [PMC free article] [PubMed] [Google Scholar] 160.Shi Z