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doi: 10.1016/j.biopha.2020.110984

Quantitative assessment of primary skin irritants in vitro in a cytotoxicity model: comparison with in vivo human irritation tests

Pirfenidone and fluorofenidone also reportedly reduced oxidative stress by enhancing MnSOD and inhibiting intracellular ROS generation, suggesting that the antioxidant effects occurred at least partially via the mitochondrial pathway in renal proximal tubular cells [55]

[DOI] [PubMed] [Google Scholar] 32.Bradley R

Herein with the improved redox sensor HyPer7, we have validated those results (Supplementary Fig