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To overcome these problems, researchers have developed various novel drug delivery systems in recent years, including pH-responsive colon-targeted granules, protein-based nanoparticles, and targeted-responsive liposomes, to improve the stability and targeted delivery of natural products in vivo (Pujara et al., 2021)

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doi: 10.1111/acel.13235, 11 BaringerS

A recent systematic review of case reports summarizing clinical outcomes and safety of apremilast in pemphigus showed that most patients experienced reductions in disease activity associated with increases in regulatory T cells and decreases in anti-Dsg antibodies, without observing any serious adverse events [54]