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doi: 10.1038/s41514-022-00083-0

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A foldable CFTRDeltaF508 biogenic intermediate accumulates upon inhibition of the Hsc70-CHIP E3 ubiquitin ligase

In addition, the magnitude of a cellular response to a ligand is determined by summation of all the signals generated by each of the occupied receptors, and therefore is related to number of receptors that are activated rather than the fraction of the total receptor pool that is bound by the ligand [26]