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Following perfusion and fixation, the animals were subjected to a wide craniectomy, and the brain, cerebellum, and brain stems were removed globally

The curve expands upon the earlier P-F (Potential Failure to Functional Failure) curve, first introduced by Nowlan and Heap in 1978, by adding the "Design" and "Installation" phases

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They highlight advances in ALS translational research that might be broadly applicable to other neurodegenerative disorders.