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Targeting epigenetic and post-translational modifications of NRF2: Key regulatory factors in disease treatment

The presence of furin cleavage site in diphtheria toxin (R-V-R-R ) and Pseudomonas exotoxin A (R-Q-P-R ), enhances their cytotoxic spectrum 339,340

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94 Among surveyed individuals with idiopathic hypersomnia (n = 88), NT1 (n = 73), and NT2 (n = 58), the COVID-19 pandemic lockdown was associated with a significant decrease in ESS scores, and shifts to teleworking were associated with a significant decrease in ESS scores and increase in sleep time versus prelockdown measurements, suggesting that maintaining a more flexible sleep schedule could benefit patients with central disorders of hypersomnia