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Depletion of adenosine has been shown to reduce fibrosis, inflammation, and vasculopathy in two preclinical mouse models of SSc 61

Vitiligo : This condition leads to the loss of skin pigment, and research suggests a potential link between vitiligo and B12 deficiency

doi:10.1002/ana.22229
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Cats with FIP often see their digestive functions altered by the progression of the virus
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