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The precise mechanisms leading to its anticancer effects are not clearly established, although multiple mechanisms affecting enzyme activity, transcription factors, cellular signalling and mitochondrial functions have been proposed

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As seen in Fig 6B, over the same reference, in nonstarved cells and at 4 h of starvation, the expression of those genes was not affected by miR-4488 overexpression
For example, one review analysis of 12 studies found that research participants who took an ALA supplement lost about 1.5 pounds more during the study periods (which averaged 14 weeks) than those who got placebos

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