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Rubber stoppers are rated for a limited number of punctures pharmaceutical literature describes approximately 10-25 punctures with standard gauge needles before coring risk increases significantly

[DOI] [PMC free article] [PubMed] [Google Scholar] 265.Hipps D, Shiba K, Henderson B, Schimmel P

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When this trial is conducted before the stages of clinical trials 1, 2, 3, and 4, its referred to as a Phase 0 study

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